Natural Sciences
Life Sciences
Scientific Computing
Life Science

Dr. Michael Hannus, siTOOLs Biotech GmbH, Martinsried

DKFZ TP3, Buchleither Seminar Room, Im Neuenheimer Feld 580

GPCF TechTalk Seminar Series

GPCF TechTalk Seminar Series: For years, RNAi was considered the magic bullet of functional genomics, promising fast, specific and scalable genetic intervention. Hype was followed by disappointment when it was shown that off-target effects frequently dominate the phenotypic response in RNAi experiments. Nevertheless, RNAi remains the standard technique for gene inactivation because of its many advantages, such as transient, dose-dependent effects and ease of arrayed screening. Complex siRNA pools apply a conceptually simple but efficient approach to prevent off-target effects: All siRNAs share the same on-target gene but have different off-target footprints. As a result, off-target effects are efficiently diluted and target gene knockdown becomes very robust.

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