Multiscale modeling of pathogen replication and spread
2016
Authors: Kumberger P, Frey F, Schwarz US, Graw F
CellNetworks People: Schwarz Ulrich
Journal: FEBS Lett. 2016 Feb 15. doi: 10.1002/1873-3468.12095

Replication and spread of human pathogens is based on the simultaneous exploitation of many different host functions, bridging multiple scales in space and time. Mathematical modeling is essential to obtain a systems-level understanding of how human pathogens manage to proceed through their life cycles. Here, we review corresponding advances for viral systems of large medical relevance, such as human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV). We will outline how the combination of mathematical models and experimental data has advanced our quantitative knowledge about various processes of these pathogens, and how novel quantitative approaches promise to fill remaining gaps.