Modelling cytoadhesion of Plasmodium falciparum-infected erythrocytes and leukocytes: common principles and distinctive features
Authors: Helms G, Dasanna AK, Schwarz US, Lanzer M
CellNetworks People: Lanzer Michael, Schwarz Ulrich
Journal: FEBS Lett. 2016 Mar 19. doi: 10.1002/1873-3468.12142

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to the microvascular endothelial lining shares striking similarities to cytoadhesion of leukocytes. In both cases, adhesins are presented in structures that raise them above the cell surface. Another similarity is the enhancement of adhesion under physical force (catch bonding). Here we review recent advances in our understanding of the molecular and biophysical mechanisms underlying cytoadherence in both cellular systems. We describe how imaging, flow chamber experiments, single molecule measurements, and computational modelling have been used to decipher the relevant processes. We conclude that although the parasite seems to induce processes that resemble the cytoadherence of leukocytes, the mechanics of erythrocytes is such that the resulting behaviour in shear flow is fundamentally different. This article is protected by copyright. All rights reserved.