A chemical switch for controlling viral infectivity
2014
Authors: Hörner M, Kaufmann B, Cotugno G, Wiedtke E, Büning H, Grimm D, Weber W
CellNetworks People: Grimm Dirk
Journal: Chem Commun (Camb). 2014 Sep 14;50(71):10319-22. doi: 10.1039/c4cc03292f

Chemically triggered molecular switches for controlling the fate and function of biological systems are fundamental to the emergence of synthetic biology and the development of biomedical applications. We here present the first chemically triggered switch for controlling the infectivity of adeno-associated viral (AAV) vectors.