Membrane fusion: SNAREs and regulation
2008
Authors: Malsam J, Kreye S, Söllner TH
CellNetworks People: Söllner Thomas
Journal: Cell Mol Life Sci. 2008 Sep;65(18):2814-32. doi: 10.1007/s00018-008-8352-3.

SNARE (SNAP receptor) proteins drive intracellular membrane fusion and contribute specificity to membrane trafficking. The formation of SNAREpins between membranes is spatially and temporally controlled by a network of sequentially acting accessory components. These regulators add an additional layer of specificity, arrest SNAREpin intermediates, lower the energy required for fusion, and couple membrane fusion to triggering signals. The functional activity of some of these regulators determines the plasticity of regulated exocytosis.