Hippocampal function in healthy carriers of the CLU Alzheimer's disease risk variant
2011
Authors: Erk S, Meyer-Lindenberg A, Opitz von Boberfeld C, Esslinger C, Schnell K, Kirsch P, Mattheisen M, Mühleisen TW, Cichon S, Witt SH, Rietschel M, Nöthen MM, Walter H
CellNetworks People: Meyer-Lindenberg Andreas, Schnell Knut
Journal: J Neurosci. 2011 Dec 7;31(49):18180-4. doi: 10.1523/JNEUROSCI.4960-11.2011

Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.