Research interests

How biological systems respond to force

 

Proteins are exposed to and tightly regulated by external perturbations, binding partners and mechanical stress, altering their assembly and reactivity. Revealing the molecular driving forces and evolutionary constraints in biomolecular systems is a requirement of designing biological materials and processes, for applications in material science and biomedicine, which is the aim of our research. Our research focuses on protein materials and fibers such as silk, disordered proteins and protein folding, the extra-cellular matrix, enzymes and allosteric proteins. Evolutionary design is a complementary aspect we consider for understanding physiological functions of these systems.