Research interests

Our group works on the molecular basis of neurological disorders, such as pain and motor dysfunction. Chronic pain has a major impact on society. Yet, a majority of chronic pain diseases are only poorly understood and elude conventional therapy. We work on pain disorders which are particularly intractable, such as tumor-induced pain, arthritis and neuropathic pain. In addition to our established spectrum of genetic approaches, behaviour and electrophysiology, we also plan on utilising in vivo imaging techniques. Several current projects involve analyses of transgenic mice which carry deletions or mutations in key pain-related molecules, such as receptors and signal transducers, such as G-proteins and protein kinases, in a spatially- and temporally-restricted manner with respect to synaptic plasticity and pain. Furthermore, we work on miRNA prolfiles in neural networks mediating pain and try to understand how endogenous genetic regulatory processes come into play to affect pain perception. Further details can be found on our website at: http://www.medizinische-fakultaet-hd.uni-heidelberg.de/Pharmakologisches-Institut.102627.0.html

 

Methods applied

conditional, region-specific gene deletion or overexpression in transgenic mice; analysis of expression and signaling complexes in the regions of the nervous system involved in pain and analgesia; miRNA profiling and functional analysis; pain behaviour in mice and elctrophyisology