Exploiting Noncovalent Interactions in an Imine-Based Covalent Organic Framework for Quercetin Delivery
2016
Authors: Vyas VS, Vishwakarma M, Moudrakovski I, Haase F, Savasci G, Ochsenfeld C, Spatz JP, Lotsch BV
CellNetworks People: Spatz Joachim
Journal: Adv Mater. 2016 Oct;28(39):8749-8754. doi: 10.1002/adma.201603006.

Covalent organic frameworks (COFs) are a new class of nanoporous polymeric vector showing promise as drug-delivery vehicles with high loading capacity and biocompatibility. The interaction between the carrier and the cargo is specifically tailored on a molecular level by H-bonding. Cell-proliferation studies indicate higher efficacy of the drug in cancer cells by nanocarrier delivery mediated by the COF.